Ann Clin Pharmacol Toxicol. 2024;4(1):ACPT-04-1032 | Open Access
Hari Prasad Sonwani
The motor symptoms of Parkinson's disease (PD) can be effectively reversed by current medications used to treat the condition, such as dopamine agonists and L-DOPA. They don't, however, significantly slow down the underlying degradation of dopaminergic neurons in the Substantia Nigra Pars Compacta (SNc), and prolonged use is linked to side effects including dyskinesia brought on by L-DOPA. ... Read more
REVIEW ARTICLE Updated Jan 11, 2024 PDF
Ann Clin Pharmacol Toxicol. 2024;4(1):ACPT-04-1031 | Open Access
Hari Prasad Sonwani* , Ritu Sahu, Seema Kishore Kumar and Alka Sen
Context and goal: K+ channels contribute to the growth of cancer cells. We have looked into how some K+ channel inhibitors affect the growth of breast cancer cells both at rest and in response to estrogen. Method of experimentation: We measured cell proliferation by radiolabelled thymidine incorporation using the mammary adenocarcinoma cell line MCF-7, either in the presence or absence ... Read more
RESEARCH ARTICLE Updated Jan 12, 2024 PDF
Ann Clin Pharmacol Toxicol. 2023;3(2):ACPT-03-1030 | Open Access
Hari Sonwani, Pragya Sahu, Rashi Bandey, Yuvraj Chandrawanshi, Prashant Verma
Background and aims: Heart failure is one cardiovascular condition that might progress due to mitochondrial dysfunction. In chronic heart failure, 3hydroxy-3- methylglutaryl-CoA reductase inhibitors (statins), which prevent the production of ROS, have cardioprotective benefits. However, it is still unknown how statins can protect the mitochondria in heart failure. Experimental strategy: Angiotensin II (1.5 mg/kg/day) or co-administered simvastatin (oral, 10 ... Read more
RESEARCH ARTICLE Updated Dec 08, 2023 PDF
Ann Clin Pharmacol Toxicol. 2023;3(2):ACPT-03-1029 | Open Access
Hari Prasad Sonwani
Numerous cellular processes, including the release of neurotransmitters and the contraction of muscles, are largely triggered and regulated by Ca2+ inflow via Ca2+ permeable ion channels. In addition, Ca2+ influx regulates cellular migration and proliferation, two mechanisms linked to cancer. This study focuses on calcium influx in breast cancer cells and discusses how future drugs for breast cancer therapy may ... Read more
REVIEW ARTICLE Updated Dec 08, 2023 PDF
Ann Clin Pharmacol Toxicol. 2023;3(2):ACPT-03-1028 | Open Access
Hari Prasad Sonwani
In a rat model of venous thrombosis, a single oral dose of 7.5 mg kg-1 of Unfractionated Heparin (UFH) lowers thrombosis by 50%. Since clinical long-term use is necessary, our goals were to investigate the antithrombotic effects of repeated oral UFH administration. Rats were given three doses of 7.5 mg kg-1 every 12, 24, 48, and 72 hours apart-as well as three or fifteen doses of 1 mg ... Read more
REVIEW ARTICLE Updated Feb 08, 2023 PDF
