J Pediatr Neonatol. 2026;6(2):JPN-06-1057 | Open Access
Kalra RK, Puthiyachirakkal M and Sampson M
Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal hyperinflammatory syndrome characterized by dysregulated immune activation, uncontrolled proliferation of lymphocytes and macrophages, and a life-threatening cytokine storm. Owing to its heterogeneous and often nonspecific presentation, HLH can be particularly difficult to recognize in the neonatal period. We report a case of neonatal familial HLH diagnosed by genetic testing despite incomplete ... Read more
CASE REPORT Updated Apr 28, 2026 PDF
J Pediatr Neonatol. 2026;6(2):JPN-06-1056 | Open Access
Rebecca Pollack
Objective: Umbilical vein varices are an uncommon occurrence in pregnancy and are usually associated with other anomalies and aneuploidies. Original case studies showed an increase in mortality attributed physiologically to varix thrombosis, increased pre-load, and subsequent fetal demise. Recent reviews have showed only an increase in growth restriction and small for gestation age neonates in isolated cases.
... Read more
CASE REPORT Updated Mar 31, 2026 PDF
J Pediatr Neonatol. 2026;6(2):JPN-06-1055 | Open Access
Ayad A, Sghir S, Sellouti M, Bahous M and Abilkassem R
Background: Hemodynamically significant patent ductus arteriosus (hsPDA) remains a frequent morbidity in preterm infants. While non-steroidal antiinflammatory drugs are traditionally used for pharmacologic closure, paracetamol has emerged as a potential alternative with a favorable safety profile.
Objective: To evaluate the efficacy of paracetamol in achieving ductal closure in preterm infants diagnosed with hsPDA in a tertiary ... Read more
RESEARCH ARTICLE Updated Mar 04, 2026 PDF
J Pediatr Neonatol. 2026;6(2):JPN-06-1054 | Open Access
Kanak Ramnani Sagar Swarnkar, Harshprabha Soni and Chittranjan Naik
Aim: To study the clinical profile and outcome in children admitted in pediatric ICU.
Objective: 1. To study the present scenario and presentation of MISC after 2 years of pandemic, 2. Treatment and outcome of pediatric patient admitted in ICU.
Material and methods: This prospective observational study was done in a tertiary care hospital located in Raipur, ... Read more
RESEARCH ARTICLE Updated Mar 04, 2026 PDF
J Pediatr Neonatol. 2025;6(1):JPN-06-1053 | Open Access
Chicoine NH, Cockrell HC and Meehan JJ
Background: Neonatal gastric perforation (GP) is rare but life-threatening, with reported mortality rates of 60% to 70%. We describe four cases of GP which occurring in premature neonates on bubble continuous positive airway pressure (CPAP) and compare our findings to the surgical literature and the FDA’s Manufacturer and User Facility Device Experience (MAUDE) database.
Methods: We ... Read more
RESEARCH ARTICLE Updated Sep 03, 2025 PDF
