Ann Genet Genom. 2021;2(1):AGG-01-1006 | Open Access
Yan Feng, Zi-HanWei, Xiao-Zhi Qiao and Yan-Chun Deng*
Epilepsy is a kind of paroxysmal brain dysfunction disease, which is the result of the imbalance between excitation and inhibition of brain neurons. Gamma- Aminobutyric acid is the most important inhibitory neurotransmitter in the brain and plays an important role in the occurrence and development of epilepsy. Abnormalities in all aspects of the metabolic pathway of GABA in the body, ... Read more
REVIEW ARTICLE Updated Jan 01, 0001 PDF
Ann Genet Genom. 2021;1(1):AGG-01-1005 | Open Access
Xue-Ying He1, Jerzy Wegiel2, R. Frank Kooy3, W. Ted Brown4,5 and Song-Yu Yang1,6*
The type 10 17β-hydroxysteroid dehydrogenase (17β-HSD10), a multifunctional protein was encoded by the HSD17B10 gene mapping to Xp11.2. An appropriate concentration of mitochondrial 17β-HSD10 is key for the maintenance of normal function of mitochondria, which is necessary for improving cellular bioenergetics and brain cognitive function. A missense and silent mutation in the HSD17B10 gene cause progressive ... Read more
RESEARCH ARTICLE Updated Jul 15, 2021 PDF
Ann Genet Genom. 2019;1(1):AGG-01-0004 | Open Access
Gyorgy Csaba
The genes of the human genome contains the information for the building of organism and for the possibilities forexecution of the program described in it. However, the genes are identical in eachcell of an organism and the epigenomic machinery selects from the gene pool the sorts, which are working in one certain cell and provokes its action as well, as ... Read more
REVIEW ARTICLE Updated Jun 26, 2019 PDF
Ann Genet Genom. 2019;1(1):AGG-01-0003 | Open Access
Gyorgy Csaba
Perinatal hormonal imprinting is taking place when the developing hormone receptors meet the target hormone at first occasion. This is needed for the normal function of receptor-hormone complex and valid for life. However, when the developmental window is open, related molecules, as endocrine disruptors also can be bound, causing life-long distortion (faulty hormonal imprinting) which could be manifested as diseases ... Read more
REVIEW ARTICLE Updated Jun 26, 2019 PDF
Ann Genet Genom. 2018;1(1):AGG-01-0002 | Open Access
Viroj Wiwanitkit
The clinical genetic investigation becomes an important kind of clinical laboratory test in the present day. There are several newly
developed molecular biology test for diagnosis and follow-up several medical problems.
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EDITORIAL Updated Dec 28, 2018 PDF
Ann Genet Genom. 2018;1(1):AGG-01-0001 | Open Access
Guanming Liu, Yun Li, Meng Yang, Pan Xu, Haitao Zhu, Shaokui Wang, Guiquan Zhang and Guifu Liu
Single Segment Substitution Lines (SSSLs) had already been demonstrated as a powerful tool on QTL analysis. However, numerous current SSSLs carried with long substitution segments. In this paper, 18 primary SSSLs were used in construction of secondary SSSLs, which were with shorter substitution segments. The 55 secondary SSSLs with an average size of 17.56 cm were achieved, which reduced markedly the size of ... Read more
RESEARCH ARTICLE Updated Dec 18, 2018 PDF