Clin Gastroenterol. 2020;2(1):CIG-02-1009 | Open Access
Ali Kirik1*, Sinan Ozcelik2, Eren Altun3, Figen Aslan4, Gulhan Zorgor Ucdu5 and Teoman Dogru6
Introduction: Dermatitis herpetiformis, a specific cutaneous manifestation of Celiac disease, is characterized by herpetiform clusters of pruritic urticated papules and vesicles on the skin and granular IgA deposits in the dermal papillae. In the present report, we describe a case of 39-year old male who is previously diagnosed as DH, and after this diagnosis he was serologically and histologically confirmed ... Read more
CASE REPORT Updated Jan 01, 0001 PDF
Clin Gastroenterol. 2020;2(1):CI-2-1008 | Open Access
Steve M D’Souza1, Lindsey B Cundra1, Byung Soo Yoo1, Parth J Parekh2 and David A Johnson3*
There is growing evidence that gastroesophageal disease is significantly influenced by the microbiome of the esophagus. Additionally, the commensal microbiome of the oropharynx, stomach, and colon are thought to have a role in the pathogenesis of gastroesophageal disease. Changes to the composition of the normal esophageal flora, notably a transition from Gram-positive to predominantly Gram-negative, affects local microbe-immune cell interaction ... Read more
REVIEW ARTICLE Updated Jan 01, 0001 PDF
Clin Gastroenterol. 2020;2(1):CIG-01-1007 | Open Access
Lindsey B Cundra BS, Steve M D’Souza, Parth J Parekh and David A Johnson
This review is intended to better define the evidence that diet modifications, sleep optimization, and melatonin supplementation could positively influence the gut microbiome and change Inflammatory Bowel Disease (IBD) disease mechanisms to improve clinical outcomes. With appropriate insight, therapeutic interventions are discussed directed to potentially alter the microbiome, as well as improve the immune response, to mitigate the disease mechanisms ... Read more
REVIEW ARTICLE Updated Jan 06, 2020 PDF
Clin Gastroenterol. 2020;2(1):CIG-01-1006 | Open Access
Lea Geisler, Niels Ubbesen, Jesper Søndergaard, Lærke Qvist Jørgensen, Trine Sam, Tobias Christensen and Mette Holst
Background: Prior work suggested a positive association between self-reported disease activity and increased fat mass in patients with Crohn’s Disease on biologic therapies.
Aims: To test the feasibility of a physical activity intervention protocol aimed at reducing the severity of symptoms in patients with Crohn’s Disease, including self-reported disease activity, fatigue and quality of life.
Methods: ... Read more
RESEARCH ARTICLE Updated Jan 06, 2020 PDF
Clin Gastroenterol. 2019;1(1):CIG-01-1005 | Open Access
Yanqing Shi, Cuiping Yang, Guangsheng Liu, Min Hu, Huan Xu, Sheng Chen, Hu Chen, Bin Liu, Han Zhao, Minhua Xie, Xijin Wang and Changchun Cai
Objective: To investigate the clinical effect of NTAN injection in acute non-variceal upper gastrointestinal bleeding.
Methods: From January 2017 to December 2018, in the department of Gastroenterology, Affiliated Hospital of Jiujiang University, 15 patients suffering from acute non-variceal upper gastrointestinal bleeding have undergone NTAN injection as the case group. At the same time, 40 patients who received routine hemostatic clips were selected as control ... Read more
RESEARCH ARTICLE Updated Nov 27, 2019 PDF
Clin Gastroenterol. 2019;1(1):CIG-01-1004 | Open Access
Changchun Cai, Cuiping Yang, Wenyin Huang, Xijin Wang, Xiangrong Ye and Junli Zuo
HCC is the third leading cause of cancer-related death and difficult to diagnose. It is very important that there is high incidence of hepatic cancer on the basis of advanced hepatic cirrhosis in which most of the cancerous cells are invasive. It is difficult to be entirely resected surgically so that many patients lost operable treatment opportunities. Transarterial Chemoembolization (TACE) ... Read more
RESEARCH ARTICLE Updated Nov 27, 2019 PDF
Clin Gastroenterol. 2019;1(1):CIG-01-1003 | Open Access
Cuiping Yang, Wei Wu, Jing Sun, Xiaojin Yang, Kun Liu, Haifeng Ying, Yanping Yang, Songyao Jiang, Xiaojun Yu, Yiqing Shi, Yufen Zhou, Shiyan Zhu, Ying Xu, Yanfei Ding, Ling Xie, Boer Cai, Xiaorong Xin, Ping Chen, Weiyu Zhang, Ren Zhao and Yunlin Wu
Background: Colorectal cancer (CRC) screening is the cornerstone in the prevention of this disease. Our study aimed to compare the multitarget stool DNA (mt-sDNA) test with the fecal occult blood test (FOBT) for CRC screening.
Methods: A total of 151 individuals were screened by colonoscopy, mt-sDNA, and FOBT, respectively, for the detection of CRC and adenoma. The results of mt-sDNA were ... Read more
RESEARCH ARTICLE Updated Nov 27, 2019 PDF
Clin Gastroenterol. 2019;1(1):CIG-01-1002 | Open Access
Amitava Goswami and Himadri Sankar Barthakur
IMAGE ARTICLE Updated Jun 26, 2019 PDF
Clin Gastroenterol. 2019;1(1):CIG-01-1001 | Open Access
Juan Zhang, Ke Chen, Linghao Wang, Xinxin Wan, Chandrama Shrestha and Zhaohui Mo
Sustained high glucose is harmful to pancreatic β-cells, resulting in impaired pancreatic β-cells proliferation. Understanding the molecular mechanisms related to β-cells proliferation is pivotal for the prevention of β-cells injury caused by glucotoxicity. The role of Phosphatase and tensin homologue (PTEN)-induced putative kinase 1 (PINK1) in the proliferation of pancreatic β-cells constantly exposed to high ... Read more
RESEARCH ARTICLE Updated Feb 13, 2019 PDF