Neurol Curr Res. 2024;3(1):NCR-03-1021 | Open Access
Leilani J Miranda, Michelle Z Chiu and Anna D Hohler
POTS (Postural Orthostatic Tachycardia Syndrome) is defined as an increase in heart rate of greater than or equal to 30 beats/minute within the initial 10 minutes of standing or Head-Up Tilt (HUT) in the absence of orthostatic hypotension. Patients with POTS can exhibit hypovolemia with treatments including IV fluid resuscitation, salt tablets and medication for heart rate control. Fluid resuscitation can ... Read more
CASE REPORT Updated Mar 13, 2024 PDF
Neurol Curr Res. 2024;3(1):NCR-03-1020 | Open Access
Felipe P Perez, Jorge Morisaki, Haitham Kanakri and Maher Rizkalla
Alzheimer’s disease (AD) is the most common neurodegenerative dementia worldwide. AD is a multifactorial disease that causes a progressive decline in memory and function precipitated by toxic beta-amyloid (Aβ) proteins, a key player in AD pathology. In 2022, 6.5 million Americans lived with AD, costing the nation $321billion. The standard of care for AD treatment includes acetylcholinesterase inhibitors (AchEIs), ... Read more
REVIEW ARTICLE Updated Jan 05, 2023 PDF
Neurol Curr Res. 2022;2(3):NCR-02-1019 | Open Access
Rafael Rivas-Vázquez , Enrique J Carrazana , Mark A Blais , Gustavo J Rey , Emma Rivas-Vázquez and Alan A Quintana
Two years into this historic pandemic, the scientific and healthcare communities continue to learn a great deal regarding COVID-19. The most urgent and immediate focus has been on vaccine development for disease prevention/mitigation and on identification of effective therapeutic interventions for acute phase of illness. However, attention is increasingly being placed on formulating treatment strategies for individuals who are ... Read more
REVIEW ARTICLE Updated Dec 30, 2022 PDF
Neurol Curr Res. 2022;2(3):NCR-1018 | Open Access
Milind Parle
Usually, every parent dreams and expects that his child excels in several fields. Therefore, almost all parents despite their varying limitations attempt to provide the best possible care, amenities, and grooming to their wards. Autism spectrum disorder is a complex, lifelong, heterogeneous, multi-factorial, developmental disability with a dynamic set of metabolic, mitochondrial, immune, neuroinflammatory, and behavioral abnormalities affecting several parts ... Read more
PERSPECTIVE Updated Sep 29, 2022 PDF
Neurol Curr Res. 2022;2(2):NCR-1017 | Open Access
Dagra A, Barpujari A, Bauer SZ, Olowofela BO, Mohamed S, McGrath K, Robinson C, Robicsek S, Snyder A and Lucke-Wold B
Epigenetic changes have been linked to a host of disease states. Besides the physiological function of epigenetic changes in regulating cellular function, recent data indicates that key changes in epigenetic activity also play an important pathophysiologic role following neurotrauma specifically. Such manifestations occur through the activation or silencing of different genes. Histone methylation has emerged as a critical component of ... Read more
REVIEW ARTICLE Updated Sep 29, 2022 PDF
Neurol Curr Res. 2022;2(2):NCR-1016 | Open Access
Ryuji Neshige
Free Zing of Gait (FOG) is a common and very disabling parkinsonian symptom, which responds unsatisfactorily to medical treatment. 100 mg of Botulinum Toxin (BTX-A) was injected in an open-label fashion into the bilateral psoas major muscles of patients with Parkinson’s disease (PD). The psoas major muscles are activated at the initiation of walking. Patient response was assessed subjectively ... Read more
RESEARCH ARTICLE Updated Sep 14, 2022 PDF
Neurol Curr Res. 2022;2(2):NCR-1014 | Open Access
Chakraborty Aand Diwan A
Alzheimer’s Disease (AD), Parkinson’s Disease (PD), and Dementia are all age-related neurodegenerative diseases. In the US, AD victims are increasing every year from 5.5 million in 2018 to 13.8 million by 2050. PD patient are calculated to increase from 7 K to 1 million by 2030. Results from accumulation of extracellular amyloid-β (Aβ) peptide and deposition of intracellular tau aggregated tangles. ... Read more
MINI REVIEW Updated May 11, 2022 PDF
Neurol Curr Res. 2022;2(2):NCR-1013 | Open Access
Shin-Tsu Chang
Myasthenia Gravis (MG) is an autoimmune disease without effective treatments. The clinical manifestation of MG is fluctuating and variable fatigue to a large extent in ocular, bulbar, limb, and respiratory muscles, which leads to major symptoms such as dysarthria, dysphagia, fatigable chewing, fatigable limb, or axial weakness. Half of these patients would progress to generalized disease within 2 years. However, symptom ... Read more
CASE REPORT Updated Apr 11, 2022 PDF
Neurol Curr Res. 2022;2(1):NCR-1012 | Open Access
Ashok Chakraborty and Anil Diwan
Parkinson’s Disease (PD) is the second highest neurodegenerative disease after Alzheimer’s and is caused by a progressive loss of dopamine producing neurons in the Substantia Nigra compacta (SNc). The disease is characterized generally by muscular tremor, difficult postures and forgetfulness, and at the molecular level is recognized by the appearance of intraneuronal α-synuclein-aggregates. Therapies at ... Read more
REVIEW ARTICLE Updated Feb 08, 2022 PDF
Neurol Curr Res. 2022;2(1):NCR-1011 | Open Access
Akash Virupakshaiah, Hind Alsharhan, Caitlin Menello, Hana Alharbi, Nicole M Engelhardt, Nicole Luongo, Can Ficicioglu and Sonika Agarwal
The diagnosis of Fabry Disease at the initial presentation can be challenging, given the spectrum of nonspecific symptoms that can mimic other common disorders requiring high clinical suspicion and careful physical examination. For patients presenting with multi-organ involvement: acroparesthesias, hypohidrosis, angiokeratomas, and signs and symptoms of cardiac, renal, cerebrovascular involvement, it is essential to include Fabry Disease in the workup. ... Read more
CASE REPORT Updated Jan 27, 2022 PDF
Neurol Curr Res. 2021;2(1):NCR-1010 | Open Access
Komolafe MA, Anele CO, Adebowale AA, Sanusi AA, Idowu AO and Fawale MB
Background: Bilateral sub-ependymal nodular cortical heterotopia associated with unilateral cerebellar hypoplasia has been infrequently reported in literature and there has been no report in association with cleft palate. It is a recognised cause of intractable epilepsy and there is no previous report in literature from Nigeria.
Case Presentation: 21-year old Nigerian man, presented with a 3-year ... Read more
CASE REPORT Updated Jul 07, 2021 PDF
Neurol Curr Res. 2021;2(1):NCR-1009 | Open Access
Ozomma S, Philip-Ephraim E*, Williams U, Oparah S, Idika K and Ohio E
Neuromyelitis Optica Spectrum Disorder (NMOSD) is an autoimmune inflammatory demyelinating disease of the Central Nervous System (CNS) which manifests with clinical features of optic neuritis, transverse myelitis, and other neurologic manifestations that may mimic multiple sclerosis. The diagnosis of NMOSD can be made using clinical, immunological and characteristic radiological features.
We report an 18-year-old male with complaints of weakness of ... Read more
CASE REPORT Updated Jun 09, 2021 PDF
Neurol Curr Res. 2020;2(1):NCR-02-1008 | Open Access
Khushpreet Brar, Shveta Sharma and Saurabh Kumar
Objective: The objective of this no interventional, 7 months observational study was to analyze the prevalence of the Cancer Related Fatigue (CRF) in cancer patient populations who was receiving chemotherapy and those who was not receiving chemotherapy.
Materials and methods: This was an observational study. Based on the inclusion and exclusion criteria , 60 subjects (24 male and 36 females) diagnosed ... Read more
RESEARCH ARTICLE Updated Sep 03, 2020 PDF
Neurol Curr Res. 2019;1(2):NCR-01-1007 | Open Access
Monge-García V, Gasparini-Berenguer R, Pérez-Cejuela C, Gabaldón L, Sánchez-payá J, Leiva- Santana C and Monge-Argilés JA
Objective: To analyze the demographic, clinical and biomarker factors that may influence the prognosis and survival in prodromal Alzheimer´s Disease (AD) in Spanish patients.
Study population and methods: Between 2008 to 2011, 170 mild cognitively impaired patients who were reviewed clinically at 6 monthly intervals were included in the study. During the follow-up, assessment of the progression to ... Read more
REVIEW ARTICLE Updated Sep 10, 2019 PDF
Neurol Curr Res. 2019;1(1):NCR-01-1006 | Open Access
Bandyopadhyay SK
In today's world, computer aided technology is touching every sphere of human life rangingfrom communication, smart systems and even medical diagnosis. One of the broadest and upcoming areas of research is biomedical image processing that includes biomedicalsignal gathering, picture processing, image forming, and display to medical diagnosisbased on various features extracted from the images. One of the most challenging ... Read more
REVIEW ARTICLE Updated Apr 08, 2019 PDF
Neurol Curr Res. 2019;1(1):NCR-01-1005 | Open Access
Ridvan Alimehmetiand Arba Cecia
Background: The life endeavor of the patient is extremely important in the pain related to specific disease.
Pain and state of malaise in chronic patients, especially in those treated for cancer is very complex. It reflects not only the advanced stage of an incurable disease, but also the psychological state with relation to the patient’s situation in ... Read more
CASE REPORT Updated Apr 04, 2019 PDF
Neurol Curr Res. 2019;1(1): NCR-01-1004 | Open Access
Saeed Shoja Shafti
Negative symptoms, which are among the main criteria in DSM-5 for diagnosis of schizophrenia, are categorized by some of the researchers into ‘primary vs. secondary ‘, ‘enduring vs. transitory ‘and ‘treatment-resistant vs. treatment-responsive’ groups. Besides, adjunctive strategies are desperately acknowledged as the necessary complementary inventions in this regard.
But according to a quantity of ... Read more
SHORT COMMUNICATION Updated Apr 04, 2019 PDF
Neurol Curr Res. 2018;1(1):NCR-01-1003 | Open Access
Valery M Kazakov, Dmitry I Rudenko, Tima R Stuchevskaya, Vladislav O Kolynin and Natalya V Shuleshova
A managed 64 with localized nodular myositis which was one of the clinical features of fibrosing polymyositis is described. In the clinical picture one could find pronounced muscle contractures of upper arm and especially of leg muscles with sharp limitation of movement’s range in large joints, together with “woody” firmness of the limb muscles with painless tumor-like ... Read more
CASE REPORT Updated Oct 29, 2018 PDF
Neurol Curr Res. 2018;1(1):NCR-01-1002 | Open Access
Mun Seong CHOI
The recent emphasis in Alzheimer’s Disease (AD) clinical research is on early disease detection, with the hope of early treatment to slow progression of AD could prevent many individuals from developing symptoms and save billions of dollars in health care costs.
Read more
SHORT COMMUNICATION Updated Sep 03, 2018 PDF
Neurol Curr Res. 2018;1(1):NCR-01-1001 | Open Access
Howard Jaster J
The typical neurologist with a clinical office practice on Main Street in Peoria probably does not spend very much time thinking
about chronic heart failure -yet. Whether that will change in the future may depend on how much researchers are able to discover
about an obscure site in the brainstem called the solitary tract nucleus. Ischemia there has ... Read more
EDITORIAL Updated Aug 23, 2018 PDF