Ann Clin Pharmacol Toxicol. 2022;3(2):ACPT-1026 | Open Access

Evaluation of the Anti-Epileptic Activity of Salvia Moorcroftiana against Pilocarpine Induced Epilepsy in Mice

Background: Allopathic drugs currently available to treat epilepsy have one or more inherent adverse effects when it comes to, the second most common neurological disorder. In this context, herbal drugs are considered much safer, potent, and have a better edge over synthetic drugs. This forced the research community to focus more on herbal remedies. Many Plants including some ... Read more

RESEARCH ARTICLE Updated Jun 24, 2022   PDF

Ann Clin Pharmacol Toxicol. 2022;3(1):ACPT-1025 | Open Access

Investigation of Potential Clinically Relevant Drug-Drug Interactions in the Context of Polypharmacy in a German Healthcare Network

Hentig NV, Koch C, Falk R, Trülzsch B, Raab HP, Winckler K, Klinsing U, Khanlari L, Odewald J, Götz S, Bayer A and Harder S

Background: In general, management of patients with polypharmacy is a challenge for medical practice. Polypharmacy often is accompanied by Adverse Drug Reactions (ADRs) due to Drug-Drug Interactions (DDIs) Objective: This study aimed to identify, categorize and appraise potentially harmful DDIs in patients with polypharmacy in the ambulatory setting. Patients and methods: A non-interventional cross-sectional study including 500 ... Read more

RESEARCH ARTICLE Updated Jun 15, 2022   PDF

Ann Clin Pharmacol Toxicol. 2022;3(1):ACPT-1024 | Open Access

COVID-19 and Practice of Remdesvir

Kumari A

Viruses have full potential to cause danger to human life and once the virus infects a cell, it tries to take over its host completely. Every animate thing from plants, animals and small bacterium are infected from virus. Read more

EDITORIAL Updated Mar 25, 2022   PDF

Ann Clin Pharmacol Toxicol. 2022;3(1):ACPT-1023 | Open Access

Cerebroprotective Effect of Talinum Triangulare in Rats Subjected to Cerebral Ischemia-Reperfusion Injury

Ghantasala VBR, Nalini M, Raghavullu BV, Annapurna A and Venkateswarlu M

Aim: The study was aimed to evaluate the cerebroprotective activity of hydroalcoholic extract of Talinum triangulare leaves against cerebral ischemia/reperfusion induced oxidative stress in wistar rats. Methods: Adult Wistar rats were anesthetized with thiopentone and subjected to global cerebral ischemia by occlusion of unilateral common carotid artery for 30 minutes followed by reperfusion. Neurobehavioral parameters, Infarct ... Read more

RESEARCH ARTICLE Updated Mar 15, 2022   PDF

Ann Clin Pharmacol Toxicol. 2022;3(1):ACPT-1022 | Open Access

Modulation of Oxidative Stress Induced Cerebral Ischemia in Wistar Rats by Hydroalcoholic Extract of Talinum triangulare

Ghantasala VBR, Nalini M, Raghavullu BV, Annapurna A and Venkateswarlu M

Background: Neuroprotection is one of considerable interest in search of novel therapies to improve ischemic brain damage in the present scenario. The objective of the present investigation is to study the actions of Talinum triangulare in cerebral ischemia/reperfusion induced oxidative stress in Wistar rats and in-vitro anti-oxidant actions. Methods: Four different groups of adult Wistar ... Read more

RESEARCH ARTICLE Updated Mar 15, 2022   PDF