Ann Clin Pharmacol Toxicol. 2024;4(1):ACPT-04-1032 | Open Access
Hari Prasad Sonwani
The motor symptoms of Parkinson's disease (PD) can be effectively reversed by current medications used to treat the condition, such as dopamine agonists and L-DOPA. They don't, however, significantly slow down the underlying degradation of dopaminergic neurons in the Substantia Nigra Pars Compacta (SNc), and prolonged use is linked to side effects including dyskinesia brought on by L-DOPA. ... Read more
REVIEW ARTICLE Updated Jan 11, 2024 PDF
Ann Clin Pharmacol Toxicol. 2024;4(1):ACPT-04-1031 | Open Access
Hari Prasad Sonwani* , Ritu Sahu, Seema Kishore Kumar and Alka Sen
Context and goal: K+ channels contribute to the growth of cancer cells. We have looked into how some K+ channel inhibitors affect the growth of breast cancer cells both at rest and in response to estrogen. Method of experimentation: We measured cell proliferation by radiolabelled thymidine incorporation using the mammary adenocarcinoma cell line MCF-7, either in the presence or absence ... Read more
RESEARCH ARTICLE Updated Jan 12, 2024 PDF
Ann Clin Pharmacol Toxicol. 2023;3(2):ACPT-03-1030 | Open Access
Hari Sonwani, Pragya Sahu, Rashi Bandey, Yuvraj Chandrawanshi, Prashant Verma
Background and aims: Heart failure is one cardiovascular condition that might progress due to mitochondrial dysfunction. In chronic heart failure, 3hydroxy-3- methylglutaryl-CoA reductase inhibitors (statins), which prevent the production of ROS, have cardioprotective benefits. However, it is still unknown how statins can protect the mitochondria in heart failure. Experimental strategy: Angiotensin II (1.5 mg/kg/day) or co-administered simvastatin (oral, 10 ... Read more
RESEARCH ARTICLE Updated Dec 08, 2023 PDF
Ann Clin Pharmacol Toxicol. 2023;3(2):ACPT-03-1029 | Open Access
Hari Prasad Sonwani
Numerous cellular processes, including the release of neurotransmitters and the contraction of muscles, are largely triggered and regulated by Ca2+ inflow via Ca2+ permeable ion channels. In addition, Ca2+ influx regulates cellular migration and proliferation, two mechanisms linked to cancer. This study focuses on calcium influx in breast cancer cells and discusses how future drugs for breast cancer therapy may ... Read more
REVIEW ARTICLE Updated Dec 08, 2023 PDF
Ann Clin Pharmacol Toxicol. 2023;3(2):ACPT-03-1028 | Open Access
Hari Prasad Sonwani
In a rat model of venous thrombosis, a single oral dose of 7.5 mg kg-1 of Unfractionated Heparin (UFH) lowers thrombosis by 50%. Since clinical long-term use is necessary, our goals were to investigate the antithrombotic effects of repeated oral UFH administration. Rats were given three doses of 7.5 mg kg-1 every 12, 24, 48, and 72 hours apart-as well as three or fifteen doses of 1 mg ... Read more
REVIEW ARTICLE Updated Feb 08, 2023 PDF
Ann Clin Pharmacol Toxicol. 2022;3(2):ACPT-1027 | Open Access
Stanley Goldberg
The French Press G-M® since 1950’s has been used in many hundreds of laboratories for biological cell disruption processing quantities from under 1 ml to 35 ml volumes and more. This transmittal covers the safety and convenience improvements of the current version, Model 11. Safety improvements include the elimination of a gap formerly under the moving platen. This pinch point is ... Read more
SHORT COMMUNICATION Updated Nov 24, 2022 PDF
Ann Clin Pharmacol Toxicol. 2022;3(2):ACPT-1026 | Open Access
Background: Allopathic drugs currently available to treat epilepsy have one or more inherent adverse effects when it comes to, the second most common neurological disorder. In this context, herbal drugs are considered much safer, potent, and have a better edge over synthetic drugs. This forced the research community to focus more on herbal remedies. Many Plants including some ... Read more
RESEARCH ARTICLE Updated Jun 24, 2022 PDF
Ann Clin Pharmacol Toxicol. 2022;3(1):ACPT-1025 | Open Access
Hentig NV, Koch C, Falk R, Trülzsch B, Raab HP, Winckler K, Klinsing U, Khanlari L, Odewald J, Götz S, Bayer A and Harder S
Background: In general, management of patients with polypharmacy is a challenge for medical practice. Polypharmacy often is accompanied by Adverse Drug Reactions (ADRs) due to Drug-Drug Interactions (DDIs) Objective: This study aimed to identify, categorize and appraise potentially harmful DDIs in patients with polypharmacy in the ambulatory setting.
Patients and methods: A non-interventional cross-sectional study including 500 ... Read more
RESEARCH ARTICLE Updated Jun 15, 2022 PDF
Ann Clin Pharmacol Toxicol. 2022;3(1):ACPT-1024 | Open Access
Kumari A
Viruses have full potential to cause danger to human life and once the virus infects a cell, it tries to take over its host completely. Every animate thing from plants, animals and small bacterium are infected from virus.
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EDITORIAL Updated Mar 25, 2022 PDF
Ann Clin Pharmacol Toxicol. 2022;3(1):ACPT-1023 | Open Access
Ghantasala VBR, Nalini M, Raghavullu BV, Annapurna A and Venkateswarlu M
Aim: The study was aimed to evaluate the cerebroprotective activity of hydroalcoholic extract of Talinum triangulare leaves against cerebral ischemia/reperfusion induced oxidative stress in wistar rats.
Methods: Adult Wistar rats were anesthetized with thiopentone and subjected to global cerebral ischemia by occlusion of unilateral common carotid artery for 30 minutes followed by reperfusion. Neurobehavioral parameters, Infarct ... Read more
RESEARCH ARTICLE Updated Mar 15, 2022 PDF
Ann Clin Pharmacol Toxicol. 2022;3(1):ACPT-1022 | Open Access
Ghantasala VBR, Nalini M, Raghavullu BV, Annapurna A and Venkateswarlu M
Background: Neuroprotection is one of considerable interest in search of novel therapies to improve ischemic brain damage in the present scenario. The objective of the present investigation is to study the actions of Talinum triangulare in cerebral ischemia/reperfusion induced oxidative stress in Wistar rats and in-vitro anti-oxidant actions.
Methods: Four different groups of adult Wistar ... Read more
RESEARCH ARTICLE Updated Mar 15, 2022 PDF
Ann Clin Pharmacol Toxicol. 2022;3(1):ACPT-1021 | Open Access
Amit Kumar and Govind Yadav
Immunomodulation is basically a process that can alter the immune system of an organism by interfering with its functions. The current approach is to know about the medicinal plants that are biologically active and could potentially be of help in the development of modern and new immunomodulating agents. As in modern-day life, extensive exposure to industry-based pollutants/xenobiotics has resulted ... Read more
REVIEW ARTICLE Updated Mar 03, 2022 PDF
Ann Clin Pharmacol Toxicol. 2021;2(2):ACPT-1020 | Open Access
Elshimaa Mohmed Eid
Novel compounds prepared by one-pot, multicomponent hantzsch reaction of 1, 1'-(butane-1,4-diyl)bis(indoline-2,3-dione), aromatic aldehydes and ammonium acetate, in presence of ethanol/nano Au-zeolite catalyst under mild condition. This research study the effect of novel synthesised 1,3-bis(2-arylimidazo[4,5-b] indol-4(3H)-yl)propane derivatives against COVID-19 main protease. Molecular docking simulation study was done using PDB:ID (7BUY) ... Read more
REVIEW ARTICLE Updated Nov 02, 2021 PDF
Ann Clin Pharmacol Toxicol. 2021;2(2):ACPT-1019 | Open Access
Gian Maria Pacifici
The currently available glycylcycline is tigecycline which is administered to children but not to infants. Tigecycline enters gram-negative bacteria by passive diffusion through channels formed by porins in the outer membrane and by active transport that pumps tigecycline across the cytoplasmic membrane. Tigecycline is more active against gram-positive than gram-negative organisms. Tigecycline is active against Streptococcus pneumoniae, methicillin-susceptible <... Read more
REVIEW ARTICLE Updated May 07, 2021 PDF
Ann Clin Pharmacol Toxicol. 2021;2(2):ACPT-1018 | Open Access
Ulisses Gabriel Vasconcelos Cunha, Frederico Brina Correa Lima de Carvalho, Débora Bertolin Duarte and Fábio Lopes Rocha
Severe Major Depression (MD) in very elderly patients usually requires a rapid response due to an increase risk of suicide and a faster clinical deterioration. In this scenario, electroconvulsive therapy constitutes the treatment option available at present. Nevertheless, not every older depressive patient is fit for a procedure which involves anesthesia and possible cardiovascular side effects. In this context, ketamine ... Read more
CASE REPORT Updated May 03, 2021 PDF
Ann Clin Pharmacol Toxicol. 2021;2(1):ACPT-1017 | Open Access
Thauann da S. Lima and Gabriel T. do Vale
The metabolic syndrome is defined as a set of physiological alterations which includes impaired glucose tolerance, dyslipidemia and hypertension. There are three generations of β-adrenergic antagonists differentiated by selectivity and affinity of the three β-adrenergic receptors. The classic β-blockers have been related to metabolic alterations as weight gain, increase of insulin resistance, which turn its use limited ... Read more
PERSPECTIVE Updated Mar 29, 2021 PDF
Ann Clin Pharmacol Toxicol. 2021;2(1):ACPT-1016 | Open Access
Gian Maria Pacifici
Trimethoprim-sulfamethoxazole, also called co-trimoxazole, is available as a single-entity preparation, and the introduction in clinic of trimethoprimsulfamethoxazole is an important advance in the treatment of bacterial infections. Trimethoprim inhibits bacterial reductase an enzyme downstream from the one that sulphonamides inhibit in the same biosynthetic sequence. This formulation consists in a dose of sulfamethoxazole 20-fold greater than that of trimethoprim, may ... Read more
REVIEW ARTICLE Updated Mar 11, 2021 PDF
Ann Clin Pharmacol Toxicol. 2021;2(1):ACPT-1015 | Open Access
Amit Kumar, Rakesh Kumar Nagar, Gurunadham Munagala, Arem Qayum, Shashank K Singh, Parvinder Pal Singh, Narendra Singh Chauhan, Shah Nawaz, Arfan Khalid, Irfan Qasam and Govind Yadav
The mutagenic potential of newly synthesized (R)-3,5-Dinitro-N-(1-(p-tolyl)ethyl)Benzamide(DNB) was assayed by the Bacterial reverse Mutation assay (AMES) at the concentration of 0, 0.32, 1.6, 8, 40, 200, 1000 and 5000 μg/plate without (-S9) and with (+S9) metabolic activation (as per OECD471). Mutagenicity was assessed using histidine dependent (his-), base pair substitution specific Salmonella typhimurium strains carrying mutation in ... Read more
RESEARCH ARTICLE Updated Feb 05, 2021 PDF
Ann Clin Pharmacol Toxicol. 2020;2(1):ACPT-02-1014 | Open Access
Chika J Mbah
Drug over dosage generally results in adverse effects (toxicity). Administration of the drug antagonist assists in reversing the adverse effects associated with the drug toxicity. Therapeutic blood or plasma concentration levels may be exceeded in the elderly, in individuals with reduced liver functions, in patients who raise the drug(s) doses as a result of tolerance and during chronic therapy. ... Read more
REVIEW ARTICLE Updated Aug 04, 2020 PDF
Ann Clin Pharmacol Toxicol. 2020;2(1):ACPT-02-1013 | Open Access
Suderio L and Perez AC
As COVID-19 spreads and increases worldwide since December 2019, the Scientists and the Medical Community are committed to find a treatment or even a vaccine. New therapies are being tested with “old” and well known medicaments but still there are many undesirable effects with each of them depending on your previous health status or age. We summarize a few ... Read more
REVIEW ARTICLE Updated Jul 27, 2020 PDF
Ann Clin Pharmacol Toxicol. 2019;1(3):ACPT-01-1012 | Open Access
Ashish Kumar Sarkar
An Ethnomedicinal survey was conducted on forestry and river regions Anuppur, tribal area of Madhya Pradesh, since this area is full of medicinal flora but their identification and continues study are lacking. Present aim of the study is to explore the tribal region having thousands of unidentified species. Ethnomedicinal data were collected using field observation and conductance of interviews of ... Read more
RESEARCH ARTICLE Updated Nov 04, 2019 PDF
Ann Clin Pharmacol Toxicol. 2019;1(3):ACPT-01-1011 | Open Access
Chika J Mbah
Chronic Obstructive Pulmonary Disease (COPD) is a preventable and treatable lung disease characterized by chronic obstruction of lung airflow that interferes with normal breathing and may be punctuated by periods of acute worsening of respiratory symptoms.
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EDITORIAL Updated Sep 13, 2019 PDF
Ann Clin Pharmacol Toxicol. 2019;1(2):ACPT-01-1010 | Open Access
Aziz S. Dobian and Hagib A. Al-Hagibi
The impact of chronic exposure of Mareb Crude Oil on the rate of oxygen consumption of the clam, Tivela Ponderosa was studied in the laboratory. The bivalve T. ponderosa is exposed to (0.5, 1 and 1.5) ml/l of Mareb Crude Oil. The oxygen consumption of bivalves T. ponderosa was controlled hourly at 5th and 10th day (every two and six hours). After 5 ... Read more
RESEARCH ARTICLE Updated Aug 07, 2019 PDF
Ann Clin Pharmacol Toxicol. 2019;1(2):ACPT-01-1009 | Open Access
Abdul Kader Mohiuddin
With over 50% of the adult population in the UK currently classified as overweight or obese, accompanied by an increased risk of type 2 diabetes and cardiovascular disease, finding more effective strategies to manage these conditions remains imperative. In 2016, World Health Organization (WHO) reported that more than 1.9 billion people in the world were overweight and over 650 million people were obese which has ... Read more
LETTER TO EDITOR Updated Aug 02, 2019 PDF
Ann Clin Pharmacol Toxicol. 2019;1(2):ACPT-01-1008 | Open Access
Mauro Luisetto, Ghulam Rasool Mashori and Kausar Rehman Khan
In today healthcare poisoning and toxicology play a relevant role in the management of patient life. Often severe cases can produce heavily consequence in patient and even exit us. To correctly treat this event are needed great organization between all services involved: emergency department, ICU, hospital pharmacy, toxicological lab, poison centre, central public institution and other.
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SHORT COMMUNICATION Updated Aug 02, 2019 PDF
Ann Clin Pharmacol Toxicol. 2019;1(2):ACPT-01-1007 | Open Access
Harikesh Maurya and Vikas Rao
Vitex negundo is a perennial plant belonging to family Verbenaceae highly distributed in the Himalayas region in India. The leaves, roots, fruits, and seeds have possessed hepatoprotective, antioxidant property, anti-inflammatory, anticancer and antioxidant properties. Generally, it required warm regions, common in waste places around villages, river banks, and most localities in the deciduous forests to grow. The V. negundo leaves ... Read more
REVIEW ARTICLE Updated Jul 11, 2019 PDF
Ann Clin Pharmacol Toxicol. 2019;1(1):ACPT-01-1006 | Open Access
García Darderes María Guadalupe, Gómez Acotto Claudia, D´Alessio Luciana and Roldán Emilio José Antonio
Introduction: Argentinean National Regulatory Health Authority became official member of the WHO Program for International Drug Monitoring in 1994.
However, the number of Adverse Drugs Reactions (ADRs) reported is still very low. Programs in Healthcare Professionals (HCP) in other countries showed that after surveys the knowledge and awareness about pharmacovigilance reporting improved, and the number of reports increase (1 to 4).
... Read more
RESEARCH ARTICLE Updated Mar 20, 2019 PDF
Ann Clin Pharmacol Toxicol. 2019;1(1):ACPT-01-1005 | Open Access
Vijai Lakshmi and Arvind Kumar Srivastava
Achyranthes Aspera linn is a vital source of drugs from the ancient time. It is known as Chirchita in hindi is an indigenous herb found in India, It has been used in almost all the traditional system of medicine, Ayurveda, Unani, and Siddha. The tribal, rural, and other people of our country commonly use this herb in various ... Read more
RESEARCH ARTICLE Updated Feb 22, 2019 PDF
Ann Clin Pharmacol Toxicol. 2018;1(1):ACPT-01-1004 | Open Access
Jayaraman Rajangam, Kiran T and Lavanya O
The aim of this study was to screen the antiamnesic activity of metformin (MET) on scopolamine (SCOP)-induced amnesia in mice. Experiments were carried out on 20 adult albino mice, divided into 4 groups, and the experimental animals were treated for 14 days with 10 mg/kg MET orally. To induce amnesia, 3 mg/kg SCOP was administered intraperitoneally. Cognitive skills of the animals were ... Read more
RESEARCH ARTICLE Updated Nov 27, 2018 PDF
Ann Clin Pharmacol Toxicol. 2018;1(1):ACPT-01-1003 | Open Access
Sidharth Mehan, Rajesh Dudi, Manju Rajput, Krishna Ghimire
Neurological disorders are a heterogeneous group of diseases of the nervous system having different etiologies. Intracerebral hemorrhage (ICH) having a common final finding, i.e., cognitive and motor impairment, and this may occur as a result of multineurotransmitter deficits, decreased availability of intracellular molecules, and axonal transporters through which the different neurons communicate with each other to maintain neuronal excitation ... Read more
REVIEW ARTICLE Updated Apr 25, 2018 PDF
Ann Clin Pharmacol Toxicol. 2018;1(1):ACPT-01-1002 | Open Access
George Kordas and Eleni Efthimiadou
We developed polymeric nanocontainers consisting of a shell with pH, T, and redox sensitivity grafted with targeting groups such as folic acid, leuprolide, and so on to target breast and prostate cancers. The quadrupole stimuli-targeted nanocontainers were loaded with doxorubicin and cisplatin called Nano4Dox and Nano4Cis platforms, respectively. In this study, we report the herapeutic efficacy of these ... Read more
REVIEW ARTICLE Updated Mar 10, 2018 PDF
Ann Clin Pharmacol Toxicol. 2018;1(1):ACPT-01-1001 | Open Access
Most Fahmida Begum, Abu Syed Md Mosaddek, Farhana Alamgir, Rumana Alim, Rezina Karim and Mahfuza Nasrin
Background: The antibiotic resistance pattern of Salmonella is ever changing over time.
Objective: This study is a retrospective analysis of the rate of isolation of Salmonella Typhi and Salmonella Paratyphi A from blood culture and their antibiotic resistance pattern.
Methods: Blood cultures submitted in Uttara Adhunik ... Read more
RESEARCH ARTICLE Updated Apr 20, 2018 PDF