J Clin Pharmacol Ther. 2024;5(1):JCPT-05-1050 | Open Access

Treatment of Severe Hypertriglyceridemia

Mark A Malesker, James M Backes and Daniel E Hilleman

Elevated triglycerides are associated with an increased risk of ASCVD. Drugs that reduce triglyceride levels have not been shown to reduce ASCVD events more than statin therapy alone. Severe hypertriglyceridemia (>500 mg/dL) increases the risk of pancreatitis, but the currently available triglyceride lowering drugs have not been shown to prevent pancreatitis. While the prevalence of severe hypertriglyceridemia is rare, ... Read more

REVIEW ARTICLE Updated Feb 14, 2024   PDF

J Clin Pharmacol Ther. 2024;5(1):JCPT-05-1049 | Open Access

Effects of Azvudine on the Low-Risk Patients Infected with COVID-19 Omicron Variants: A Retrospective Case-Control Study

Xiaogao Jin, Qinjun Chu, Jie Wang, Chenxi Zhang, Hailong Bing, Liwei Sun, Wenchuan Guan, Hang Bao, Jieshi Ba, Dachao Yun, Dan Wang, Jiwei Wang, Ningwei Yin and Hongkai Lian

Objective: To evaluate the efficacy and safety of Azvudine in treatment of the patients infected with COVID-19 Omicron variants.
Methods: This study included the discharged patients after COVID-19 infection from October 17 to November 17 in 2022 in Zhengzhou Central Hospital. The patients were divided into two groups, the Symptomatic Treatment group (ST) and the Symptomatic Treatment and oral Azvudine (STA) groups ... Read more

RESEARCH ARTICLE Updated Feb 12, 2024   PDF

J Clin Pharmacol Ther. 2023;4(3):JCPT-04-1048 | Open Access

End of Craving with Endoxifen in Substance Use & Bipolar Disorder

Hema Tharoor

This case report brings to light the role of Endoxifen, a tamoxifen metabolite and direct Protein Kinase inhibitor drug in Substance use and Bipolar disorder. The putative action of Endoxifen in reducing alcohol consumption and implications as a possible anti craving agent is highlighted. Read more

CASE REPORT Updated Oct 20, 2023   PDF

J Clin Pharmacol Ther. 2023;4(3):JCPT-04-1047 | Open Access

A Review on Acorus Calamus Linn

Subhashini Dukkipati

REVIEW ARTICLE Updated Sep 04, 2023   PDF

J Clin Pharmacol Ther. 2023;4(3):JCPT-04-1046 | Open Access

Investigating the Activity of Ethanol Extract of Gongronema Latifolium Leaf on High Fat Diet-Induced Hyperlipidemia in Wistar Rats

Tharcitus Chilaka Onwudiwe, Malachy Ifeanyi Obi, Kingsley Chimsorom Chilaka and Richard Ikechukwu Eze

Hyperlipidemia, a disorder of lipid metabolism, is rising at alarming rate in the global population and has been noted to pose various cardiovascular health challenges. Synthetic drugs used in the treatment of this disorder are associated with remarkable adverse effects and consequently, poor patient compliance. Plant remedies are not only advancing in the treatment of human ailments, but also have ... Read more

RESEARCH ARTICLE Updated Jul 20, 2023   PDF