J Clin Pharmacol Ther. 2025;6(1):JCPT-06-1070 | Open Access
Lingyu Li, Le Zhu, Mo Chen, Tianchen Yang, Ya Zhao and Zhiyu Shao
Background: Epiphyllum oxypetalum (DC.) Haw. is a plant of great ornamental value. In recent years, it has been gradually used in food and cosmetics, especially in cosmetics. Aims: Delve into the ingredients of E. Oxypetalum (DC.) Haw. to explore their beauty effects.
Methods: The ingredients of E. Oxypetalum (DC.) Haw. were isolated and purified by HLB ... Read more
RESEARCH ARTICLE Updated May 03, 2025 PDF
J Clin Pharmacol Ther. 2025;6(1):JCPT-06-1069 | Open Access
Vishal Rastogi, Riya Mahar, R1Amity Institute of Pharmacy, Indiaavi Maurya, Nithya Shanthi and Priyanka Saroj
Biosimilars are biologic drugs highly similar to an already approved reference biologic. They are transforming advanced therapeutic areas by increasing patient access to these drugs and lowering their costs. Guidelines for biosimilars have been established around the world but can be inconsistent and often reflect the inherent challenges associated with the adoption of biosimilars. For example, the first comprehensive biosimilar ... Read more
REVIEW ARTICLE Updated May 02, 2025 PDF
J Clin Pharmacol Ther. 2025;6(1):JCPT-06-1068 | Open Access
Sam T Donta
Lyme Disease is an infectious disease that may become a persistent illness. The causative organisms are sensitive in vitro to many antibiotics, but there are numerous patients with persisting symptoms that have had difficulty resolving those symptoms with standardly recommended antibiotic treatments. Herein is described the pharmacologic basis for the successful treatment of persistent Lyme disease, using ... Read more
REVIEW ARTICLE Updated Apr 17, 2025 PDF
J Clin Pharmacol Ther. 2025;6(1):JCPT-06-1066 | Open Access
Camila Heredia, Moizza Zia Ul Haq and Navindra Persaud
Background: Medicines with the same molecular structure have similar clinical effects but can have different societal impacts including those related to drug spending and access. This study examined how countries prioritize access to such medicines using national essential medicines lists as a metric.
Methods: In May 2023, we reviewed 158 national essential medicines lists to identify molecularly and clinically equivalent medicine pairs, ... Read more
RESEARCH ARTICLE Updated Mar 26, 2025 PDF
J Clin Pharmacol Ther. 2025;6(1):JCPT-06-1065 | Open Access
Spataro F1*§, Desantis V§2, Di Girolamo A1, Ria R2, Vacca A2 and Solimando AG2
Colchicine is an anti-inflammatory drug essential for treating recurrent pericarditis, gout, and familial Medi-terranean fever. Despite its benefits, hypersensitivity reactions, such as urticaria and angioedema, can limit its use, posing a significant challenge in managing conditions like pericarditis. Desensitization protocols may enable patients with hypersensitivity to safely resume colchicine therapy.
A 30-year-old woman with recurrent pericarditis developed a hypersensitivity reaction, ... Read more
CASE REPORT Updated Jan 06, 2025 PDF
J Clin Pharmacol Ther. 2024;5(3):JCPT-05-1064 | Open Access
Jessica M. Van Laren, James M. Backes and Daniel E. Hilleman
Weight loss drugs are indicated for the optimization of health in obese or overweight patients with comorbidities. Weight loss should lead to improvements in lipids, Hgb A1c, and blood pressure. This review addressed the impact of weight loss achieved with drug therapy and the relative magnitude of changes in cardiometabolic parameters observed in randomized placebo-controlled trials. The magnitude of ... Read more
RESEARCH ARTICLE Updated Dec 13, 2024 PDF
J Clin Pharmacol Ther. 2024;5(3):JCPT-05-1063 | Open Access
Maodi Gong, Hua Shi, Yikun Wu, Yuangao Xu, Guangyi Hong, Wei Chen and Shuxiong Xu
Renal Ischemia-Reperfusion (I/R) injury can cause renal insufficiency, leading to the need for renal replacement therapy in severe cases, placing a substantial burden on patient recovery and life. Mitigating renal I/R injury is a current research focus. Protein kinase C (PKC) isozymes, with PKCβII as the primary isoform in the kidney, are crucial protein kinases. Ferroptosis ... Read more
RESEARCH ARTICLE Updated Dec 02, 2024 PDF
J Clin Pharmacol Ther. 2024;5(3):JCPT-05-1062 | Open Access
Lin Yimin and Hong Qingxia
Purpose: This study aims to investigate the Adverse Drug Event (ADE) signals associated with potassium ion adhesive sodium cyclozirconate using the United States Food and Drug Administration's Adverse Event Reporting System (FAERS), providing insights for its safe clinical application.
Methods: Adverse reactions related to Sodium Zirconium Cyclosilicate (SZC) were retrieved from the FAERS database, covering the period from May 2018 ... Read more
RESEARCH ARTICLE Updated Nov 20, 2024 PDF
J Clin Pharmacol Ther. 2024;5(3):JCPT-05-1061 | Open Access
Sancilio Frederick, Madsen Martin, Dariani Magshoud and Singh Gurpreet
Psilocin mucate (L-130), a stabilized form of psilocin (US Patent 12,102,616), offers a potentially superior option for oral therapeutic formulations compared to psilocybin. A Phase 1, open-label, single-dose pharmacokinetic study was conducted in 10 healthy volunteers to assess the safety, bioavailability, and pharmacokinetic profile of psilocin mucate. The results demonstrated rapid absorption, highly reproducible inter-subject variability and 100% bioavailability. T he compound was well-tolerated, ... Read more
RESEARCH ARTICLE Updated Oct 19, 2024 PDF
J Clin Pharmacol Ther. 2024;5(3):JCPT-05-1060 | Open Access
George A, Shahul KS, Reji A and Devananda H
Aim and Objective: The study aims to assess the safety profile of Tofacitinib among Autoimmune Rheumatic Disease (ARD) patients in real life, attending the Rheumatology outpatient department of a tertiary care hospital. This short-term prospective observational study was done for 6 months involving 50 ARD patients. Patient's socio-demographic and clinical data were recorded in a predesigned proforma and were analysed for ... Read more
RESEARCH ARTICLE Updated Sep 19, 2024 PDF
J Clin Pharmacol Ther. 2024;5(3):JCPT-05-1059 | Open Access
Hema Tharoor, Sindhu Maran, Shreya Saravanan and Dinesh Selvan
Pharmacological interventions used in the treatment of severe mental disorders are leading to secondary conditions such as weight gain and metabolic syndrome. Introducing probiotics as an add on therapy is observed to aid in improving metabolic parameters such as blood sugars and lipid profile. The present study was conceived to understand the role and impact of probiotics on clinical and ... Read more
RESEARCH ARTICLE Updated Aug 28, 2024 PDF
J Clin Pharmacol Ther. 2024;5(2):JCPT-05-1058 | Open Access
Liu R, Shen L, Jiang H, Wang Z, Li D, Yan K and Fan Z
Introduction: Platelet activation may be involved in the pathophysiology of psoriasis contributing to increased cardiovascular risks. The study aimed to evaluate the association between platelet activation and psoriasis severity by investigating the values of novel activation markers.
Materials and methods: The levels of Immature Platelet Fraction (IPF), Immature Platelet Count (IPC), Mean Platelet Volume (MPV), and Platelet Distribution Width (... Read more
RESEARCH ARTICLE Updated Jun 05, 2024 PDF
J Clin Pharmacol Ther. 2024;5(2):JCPT-05-1057 | Open Access
Kaushal Lalita, Chand Duni, Kumari Alka, Arti, Arya Ekta and Chauhan Narendra Singh
Traditionally used "Restorative Herb", Thalictrum Foliolosum contains rich bioactive compounds with potent free radical scavenging properties. This study explored its potential to combat liver damage. Root extracts (methanolic, ethanolic, hydro alcoholic, aqueous) were assessed for their content of flavonoids and phenolics, known for their antioxidant effects. The study induced liver damage in rats using paracetamol and then evaluated ... Read more
RESEARCH ARTICLE Updated Jun 03, 2024 PDF
J Clin Pharmacol Ther. 2024;5(2):JCPT-05-1056 | Open Access
Sancilio Frederick, Dariani Magshoud, Singh Gurpreet, Sutariya Rakesh and Chavda Purvi
Psilocybin and its active metabolite, psilocin, are potent psychoactive tryptamines naturally prevalent in Psilocybin mushrooms. They are being investigated for possible therapeutic applications in the treatment of several neurological disorders, depression, post traumatic stress disorder, obsessive-compulsive disorder, anxiety, addiction, and cluster headaches. Recent reports have broadened these investigations to include treatments as anti-inflammatory agents that cross the blood-brain barrier. Although ... Read more
REVIEW ARTICLE Updated May 20, 2024 PDF
J Clin Pharmacol Ther. 2024;5(2):JCPT-05-1054 | Open Access
Reshma Kumari and Sanjay Kumar
Green tea, derived from the Camellia sinensis plant known for its retention of natural substances found in fresh leaves, ranks as the world's second most consumed beverage after water, with various pharmacologically active components including tea polyphenols, alkaloids, amino acids, polysaccharides, and volatile compounds, isolated and identified from it. Recent studies have highlighted green tea's versatile pharmacological activities ... Read more
RESEARCH ARTICLE Updated May 18, 2024 PDF
J Clin Pharmacol Ther. 2024;5(1):JCPT-05-1053 | Open Access
Yingying Yang, Zhigang Xiao, Jing Ouyang and Yan Guo
Myopia is a growing concern in adolescents worldwide. This retrospective case study evaluated the efficacy of combining 0.01% atropine with orthokeratology lenses to control myopia progression in children. Results from 33 patients showed a significant reduction in axial length growth with the combined treatment, without notable changes in UCVA and IOP. Significant improvements were seen in TBUT and pupil diameter. Age was ... Read more
RESEARCH ARTICLE Updated May 10, 2024 PDF
J Clin Pharmacol Ther. 2024;5(1):JCPT-05-1052 | Open Access
Karine Mathurin, David Bloom, Jason A Gross and Jean Lachaine
Objective: Though clozapine products have the same clinical benefits, Patient Support Programs (PSPs) may have an impact on treatment persistence. This study aimed to evaluate the impact of clozapine PSPs on treatment persistence, from the Quebec perspective.
Methods and analysis: An 18-month persistence study was conducted using data from the Régie de l’ Assurance Maladie du ... Read more
RESEARCH ARTICLE Updated May 09, 2024 PDF
J Clin Pharmacol Ther. 2024;5(1):JCPT-05-1050 | Open Access
Mark A Malesker, James M Backes and Daniel E Hilleman
Elevated triglycerides are associated with an increased risk of ASCVD. Drugs that reduce triglyceride levels have not been shown to reduce ASCVD events more than statin therapy alone. Severe hypertriglyceridemia (>500 mg/dL) increases the risk of pancreatitis, but the currently available triglyceride lowering drugs have not been shown to prevent pancreatitis. While the prevalence of severe hypertriglyceridemia is rare, ... Read more
REVIEW ARTICLE Updated Feb 14, 2024 PDF
J Clin Pharmacol Ther. 2024;5(1):JCPT-05-1049 | Open Access
Xiaogao Jin, Qinjun Chu, Jie Wang, Chenxi Zhang, Hailong Bing, Liwei Sun, Wenchuan Guan, Hang Bao, Jieshi Ba, Dachao Yun, Dan Wang, Jiwei Wang, Ningwei Yin and Hongkai Lian
Objective: To evaluate the efficacy and safety of Azvudine in treatment of the patients infected with COVID-19 Omicron variants.
Methods: This study included the discharged patients after COVID-19 infection from October 17 to November 17 in 2022 in Zhengzhou Central Hospital. The patients were divided into two groups, the Symptomatic Treatment group (ST) and the Symptomatic Treatment and oral Azvudine (STA) groups ... Read more
RESEARCH ARTICLE Updated Feb 12, 2024 PDF
J Clin Pharmacol Ther. 2023;4(3):JCPT-04-1048 | Open Access
Hema Tharoor
This case report brings to light the role of Endoxifen, a tamoxifen metabolite and direct Protein Kinase inhibitor drug in Substance use and Bipolar disorder. The putative action of Endoxifen in reducing alcohol consumption and implications as a possible anti craving agent is highlighted.
Read more
CASE REPORT Updated Oct 20, 2023 PDF
J Clin Pharmacol Ther. 2023;4(3):JCPT-04-1047 | Open Access
Subhashini Dukkipati
REVIEW ARTICLE Updated Sep 04, 2023 PDF
J Clin Pharmacol Ther. 2023;4(3):JCPT-04-1046 | Open Access
Tharcitus Chilaka Onwudiwe, Malachy Ifeanyi Obi, Kingsley Chimsorom Chilaka and Richard Ikechukwu Eze
Hyperlipidemia, a disorder of lipid metabolism, is rising at alarming rate in the global population and has been noted to pose various cardiovascular health challenges. Synthetic drugs used in the treatment of this disorder are associated with remarkable adverse effects and consequently, poor patient compliance. Plant remedies are not only advancing in the treatment of human ailments, but also have ... Read more
RESEARCH ARTICLE Updated Jul 20, 2023 PDF
J Clin Pharmacol Ther. 2023;4(2):JCPT-04-1045 | Open Access
Taoreed Adegoke Azeez
Background: Diabetes mellitus is highly prevalent in Nigeria. In addition to lifestyle changes, hypoglycaemic agents are of crucial importance in providing optimal care. The study aimed to study the pattern of hypoglycaemic agents and glycaemic control.
Methods: It is a retrospective study. Parameters of interest were obtained from the electronic medical records of 248 type 2 diabetes patients.
Results: The mean ... Read more
RESEARCH ARTICLE Updated Jul 05, 2023 PDF
J Clin Pharmacol Ther. 2023;4(2):JCPT-04-1044 | Open Access
Namitha A, Jadav Sarma, Sumitra Debnath and Archana Hazarika
Curcumin, Eugenol, Nanocurcumin, Nanoeugenol and their combinations were known for their medicinal values especially their anti-viral effects against various viruses. Nanocurcumin and Nanoeugenol prepared by Evaporative Precipitation of Nanosuspension (EPN) and ultrasonication method had Z-average particle size of 64.22 nm and 7.270 nm, respectively which was found to be physically stable without any phase separation. The nano-ointment was prepared by the combination ... Read more
RESEARCH ARTICLE Updated May 04, 2023 PDF
J Clin Pharmacol Ther. 2023;4(2):JCPT-04-1043 | Open Access
Sumitra Debnath, Archana Hazarika and Jadav Sarma
Background: Nyctanthes arbor-tristis commonly known as Harsinghar, Night jasmine or Parijat. The present study was an attempt to evaluate the antiinflammatory activity of N. arbor-tristis leaf extract.
Method: Melonex was used as standard drug for evaluation of anti-inflammatory activity by Carrageenan induced hind paw oedema. The anti-inflammatory activity of the ethanolic, hydroethanolic, aqueous and chloroform extracts of N. arbor-tristis ... Read more
RESEARCH ARTICLE Updated May 04, 2023 PDF
J Clin Pharmacol Ther. 2023;4(2):JCPT-04-1042 | Open Access
Garcia-Molina A, Pascual-Carbonell D and Canadell-Vilarrasa L
This medical case report describes the treatment of a 59-year-old male patient with Multiple Myeloma (MM), who was admitted to the hospital with a fractured vertebra caused by an accidental fall. The patient was undergoing the VRd protocol, which consists of bortezomib, lenalidomide, and dexamethasone. Before the start of the third cycle, the patient had evidence of hyponatremia due to ... Read more
CASE REPORT Updated May 01, 2023 PDF
J Clin Pharmacol Ther. 2023;4(2):JCPT-04-1041 | Open Access
Bruna Genari, Rayara dos Santos Goncalves, Breno Dias do Vale, Roberto Carlos Abadia de Oliveira, Felipe Weidenbach Degrazia and Bruna Frizon Greggianin
Background: The term endoperiodontal lesion or endo-perio is used to describe lesions which inflammatory products are found both in the periodontium and in the pulp. Due to this endodontic and periodontal interrelation, several classifications of endo-periodontal lesion changes have been described, and for years the one that was most used were based on the disease's etiological sequence. The current &... Read more
CASE REPORT Updated Apr 28, 2023 PDF
J Clin Pharmacol Ther. 2023;4(1):JCPT-04-1040 | Open Access
Wensha Nie, Huiping Wang, Tiesong Zhang, Xia Zhang, Ou Zhang, Jiawu Yang, Shangkun Wang and Chunxia Wang
Objective: To explore the clinical characteristics and diagnosis of Glucose Transporter 1 Deficiency Syndrome (GLUT1-DS), and analyze the diagnostic significance of functional movement disorders.
Method: The clinical data of 3 children with GLUT1-DS were collected to analyze their clinical manifestations.
Results: Three cases of male patients with SLC2A1 gene mutation were included in this retrospective study. All ... Read more
RESEARCH ARTICLE Updated Apr 28, 2023 PDF
J Clin Pharmacol Ther. 2023;4(1):JCPT-04-1039 | Open Access
Shalabh Jauhari, Shatakshi Rai and Reenoo Jauhari
Diabetes mellitus is a group of metabolic diseases characterized by chronic hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The classical classification of diabetes as proposed by the American Diabetes Association (ADA) in 1997 as type 1, type 2, other types, and Gestational Diabetes Mellitus (GDM) is still the most accepted classification and adopted by ADA. Type 1 Diabetes Mellitus is ... Read more
RESEARCH ARTICLE Updated Apr 17, 2023 PDF
J Clin Pharmacol Ther. 2023;4(1):JCPT-04-1038 | Open Access
Yunfei Li, Huali Liu, Linlin Ding, Liwei You, Yuqiang Zhang, Xingxing Wang, Xueyuan Lin and Liquan Yang
The pathogenesis of an ovarian disease is connected with PTN and its receptor Protein Tyrosine Phosphatase Receptor Z1 (PTPRZ1). Paclitaxel is the first-line drug for the therapy of ovarian cancer. With the increment of paclitaxel chemotherapy, paclitaxel obstruction happens in the late phase of therapy frequently. By treating A2780 and SKOV-3 cells with PTN, we found the development of the ... Read more
RESEARCH ARTICLE Updated Mar 23, 2023 PDF
J Clin Pharmacol Ther. 2023;4(1):JCPT-04-1036 | Open Access
Rubin Zareski
Achievement of sustainable economic stability and growth in the last 15 years was influenced by the absence or inconsistence of structural reforms in the major world economies. Negative or zero growth trends in the country’s GDP have significantly affected the Pharma industries, forcing them to shift and/or reduce the costs in all horizontal areas of business, affecting among ... Read more
RESEARCH ARTICLE Updated Jan 28, 2023 PDF
J Clin Pharmacol Ther. 2022;3(2):JCPT-03-1035 | Open Access
Ferrara M, Trevisan G, Marinaro L, Accardo G, Fantino S, Alladio F, Drappero E, Tettoni M, De Vivo E, Ianniello A, De Nicolò A, D’AvolioA, Calcagno A and Bonora S
Background: Doravirine (DOR) and Rilpivirine (RPV) are the NNRTIs currently most used in the clinical setting, in dual and triple drug regimens (2DR and 3DR). Intracellular (IC) Pharmacokinetics (PK) of these drugs has not been fully elucidated. Our aim was to compare plasma PK and IC accumulation in real-life experienced patients (pts).
Methods: Pts on DOR- and RPV-including Antiretroviral (... Read more
SHORT COMMUNICATION Updated Dec 22, 2022 PDF
J Clin Pharmacol Ther. 2022;3(2):JCPT-03-1034 | Open Access
Yu Kyong Kim, Young-Sim Choi, Won Tae Jung, Kyu-Yeol Nam, Jae Seok Roh, Youn-Woong Choi, Sang-Min Cho, Do-Hyung Ki, Tae-Wan Kim, Hye J. Lee, Su Jeong, Min Kyu Park, Ha-Yeon Kim, Ji Hyeon Lee and Jun Gi Hwang
Purpose: Proton-pump inhibitors, such as rabeprazole, are prone to degradation in stomach acid. The use of Enteric-Coated (EC) forms minimizes this problem; however, these forms have slower onset time. The Pharmacokinetics (PK) and Pharmacodynamics (PD) of rabeprazole in a Fixed-Dose Combination (FDC) tablet with sodium bicarbonate, which was used to raise the intragastric pH, and in a conventional EC tablet ... Read more
RESEARCH ARTICLE Updated Dec 20, 2022 PDF
J Clin Pharmacol Ther. 2022;3(2):JCPT-03-1033 | Open Access
Oliva B, Gómez NA and Fernández JR
Cancer is a disease with high incidence. Other therapies as surgery and radiotherapy are also used in the treatment of this disease. However, the effect adverse and the metastasis limited the use of these therapies. Target anticancer Targeted cancer treatment is an attractive approach where drugs or other substances which targets specific molecules to block the growth and spread of ... Read more
RESEARCH ARTICLE Updated Dec 16, 2022 PDF
J Clin Pharmacol Ther. 2022;3(2):JCPT-03-1032 | Open Access
Serdar Ferit Toprak, Muhammed Ayral and Serkan Dedeoglu
Objectives: The relationship between vitamin D and laryngomalacia is not fully known. Our study aimed to investigate whether there is any relationship between laryngomalacia and vitamin D.
Materials and methods: Thirty-two patients under one year of age with a diagnosis of laryngomalacia without any other disease were included in our study. Anamnesis, physical examination, and examination with a flexible ... Read more
SHORT COMMUNICATION Updated Dec 05, 2022 PDF
J Clin Pharmacol Ther. 2022;3(2):JCPT-03-1031 | Open Access
Himmatrao Saluba Bawaskar and Pramodini Himmatrao Bawaskar
Rabies glycoprotein outer content of rabies viral cell wall downgrade virion infected cellular apoptosis. Cellular apoptosis inversely related to virulence of virus. Beta bungarotoxin of krait (Bungarus Caeruleus) venom molecular structure similar to the glycoprotein of the rabies virus. The antibodies or immunoglobulin against the krait venom (beta-bungarotoxin) para- specially inhibit the viral glycoprotein and upgrade the apoptosis of infected ... Read more
SHORT COMMUNICATION Updated Dec 05, 2022 PDF
J Clin Pharmacol Ther. 2022;3(2):JCPT-03-1030 | Open Access
Samira Jafari, Mohsen Meimanatabadi, Mehdi Meimanatabadi, Hossein Meimanatabadi and Cédric Delattre
Teeth discoloration is one of prevalent aesthetic concerns resulted from intrinsic/extrinsic reasons. Bleaching process can be a valuable treatment for patients with severe discolorations, which can cause an immediate change in their teeth color. According to literature review, use of commercial products owing to their high concentration of hydrogen peroxide can lead to lessen the enamel microhardness. Regarding these ... Read more
RESEARCH ARTICLE Updated Dec 05, 2022 PDF
J Clin Pharmacol Ther. 2022;3(1):JCPT-03-1028 | Open Access
Chunggoo Kim, Hyun Soo Shim, Yujung Chang, Hyeonjoo Im and Junsang Yoo
What is known and objectives: Spinal Cord Injury (SCI) is defined for the last few decades as patients getting wheelchair bound and under medication for a lifetime [1]. Medical battery for SCI is very limited which often results in heightened frustration for the caregivers who land up with no solid solution to the condition. However, in recent times due to the ... Read more
REVIEW ARTICLE Updated Oct 03, 2022 PDF
J Clin Pharmacol Ther. 2022;3(1):JCPT-03-1027 | Open Access
Victor T Wilcox, Sarah D George, Pamela B Yang, Cruz Reyes-Vazquez and Nachum Dafny
Methylphenidate (MPD) is a psychostimulant widely used to treat ADHD. MPD consumption has increased among ordinary people as a cognitive enhancer and recreational drug across multiple age groups. Due to the close pharmacological profile it shares with cocaine and amphetamines there is concern that MPD has the potential to elicit dependence and abuse. The object of this study was to ... Read more
RESEARCH ARTICLE Updated Sep 14, 2022 PDF
J Clin Pharmacol Ther. 2022;3(1):JCPT-03-1026 | Open Access
Dafny N, Reyes-Vasquez C and Liu Y
Methylphenidate (MPD) is a CNS stimulant known for its treating behavioral disorders. The increase in its use among “normal” individuals for cognitive enhancement and recreation has become a serious public health problem. This study reveals that acute MPD exposure elicits mainly increases in neuronal and behavioral activity in dose response characteristics. Chronic exposure of MPD compared to acute (0.6, 2.5 ... Read more
RESEARCH ARTICLE Updated Sep 14, 2022 PDF
J Clin Pharmacol Ther. 2022;3(1):JCPT-03-1025 | Open Access
Xiaodong He, Youcheng Zhang, Chao Niu, Xiaogang Li, Bo Li and Ruofei Sun
Breast cancer is one of the leading causes of cancer-related mortality worldwide and is the most common malignancy in women. Breast cancer is not only highly prevalent and aggressive, but also highly susceptible to recurrence and metastasis, which greatly restricts its clinical treatment outcome. In recent years, miRNAs have been shown to be closely related to the recurrence and metastasis ... Read more
RESEARCH ARTICLE Updated Feb 16, 2022 PDF
J Clin Pharmacol Ther. 2022;3(1):JCPT-03-1024 | Open Access
Al-kuraishy HM, Al-Gareeb AI, Hussain HN and Al-Shuely AA
King Kong is a 2005 epic monster adventure movie co-authored, produced and directed by Peter Jackson. A second edition of the 1933 movie of the same title, movie stars Naomi Watts, Jack Black, Adrien Brody. Set in 1933, the movie follows the story of an ambitious director forcing his crew to travel to the mysterious Skull Island. There, they encounter prehistoric creatures living ... Read more
LETTER TO EDITOR Updated Jan 20, 2022 PDF
J Clin Pharmacol Ther. 2021;2(3):JCPT-02-1023 | Open Access
Tahmina Zahan, Morshed Nasir, Abdul Quddus Shohag, Rawshan Ara perveen, Sayma Parvin and Abdul Quddus Shohag
Background: The objective was to perceive the demographic characteristics, clinical symptoms, comorbidities, and biomarkers (hematological, inflammatory, hepatic, renal, and metabolic) of Intensive Care Unit admitted survivors and deceased patients with coronavirus and link with ABO system admitted to a tertiary level hospital in Dhaka, Bangladesh. Methods: It was a retrospective cohort, conducted in Holy Family Red Crescent Medical College Hospital, ... Read more
RESEARCH ARTICLE Updated Nov 24, 2021 PDF
J Clin Pharmacol Ther. 2021;2(3):JCPT-02-1022 | Open Access
Frank Comhaire and Jan Pen
Background and objectives: Other than the direct impact of cardiopulmonary sequelae, COVID-19 disease may cause persistent signs and symptoms describes as post-COVID syndrome or long COVID. The clinical presentation and neuroimaging aspects of patients suffering from this condition are remarkably similar to those seen in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Inflammation, immune disorder and oxidative damage ... Read more
RESEARCH ARTICLE Updated Nov 10, 2021 PDF
J Clin Pharmacol Ther. 2021;2(3): JCPT-02-1021 | Open Access
Yuji Tezuka, Osamu Sekine, Akiko Hirano, Yukako Hanada, Kayo Harada, Choka Azuma, Yukako Yamamoto, Jun Ito Kobayashi, Miki Washiyama, Masanori Iwanishi, Masao Kanamori, Akira Shimatsu and Atsunori Kashiwagi
We conducted a prospective open-label, short-term, and double-arm exploratory study to investigate changes in the skin hydration state in Japanese patients with Type 2 Diabetes Mellitus (T2DM) treated with either 50 mg ipragliflozin (a Sodium-Glucose Cotransporter-2 Inhibitor: SGLT2i) (n=8) or 50 mg sitagliptin (as a control) (n=6) 1×/day for 14 days. We performed a post-hoc analysis of reported clinical data to ... Read more
SHORT COMMUNICATION Updated Oct 27, 2021 PDF
J Clin Pharmacol Ther. 2021;2(3):JCPT-02-1020 | Open Access
Nilgun Eroglu, Ömer Akcal, Metin Cil, Hatice Mutlu Albayrak and Dilek Karagoz
Activated PI3K-Delta Syndrome (APDS) is an immunodeficiency caused by gain-of-function mutations in PIK3CD. This disease exhibits complex immune phenotypes including increased IgM, recurrent infection, and impaired vaccine responses. Patients with APDS also experience other complications including lymphoid hyperplasia, autoimmunity, increased susceptibility to herpes viruses, especially Epstein-Barr virus and cytomegalovirus, and an increased incidence of B-cell lymphoma. In this ... Read more
CASE REPORT Updated Oct 07, 2021 PDF
J Clin Pharmacol Ther. 2021;2(2):JCPT-02-1019 | Open Access
Omer Akcal, Ilke Taskirdi, Selime Ozen, Idil Akay Haci, Semiha Bahçeci Erdem, Sait Karaman, Nesrin Gulez and Ferah Genel
Autosomal recessive Agammaglobulinemia (ARA) is an uncommon type of congenital Agammaglobulinemia characterized by the absence of any of the molecules that constitutes the pre-B cell receptor complex at the B lymphocyte developmental stages. ARA is defined by profound hypogammaglobulinemia of all immunoglobulin isotypes and absence of circulating B lymphocytes. Herein, we report an atypical case of ARA with λ5/14.1 deficiency ... Read more
CASE REPORT Updated Sep 24, 2021 PDF
J Clin Pharmacol Ther. 2021;2(2):JCPT-02-1018 | Open Access
Cao yuming, Chen zhenlie, Chen huijun, Guo juanjuan, Yu xuechen and Zhang yuanzhen
Effective detection and treatment of COVID-19 is still a major challenge. However, a comprehensive and detailed description of the changes experienced by human placental immune cells after COVID-19 infection is still lacking. Here, we performed proteomic profiling of placenta from 5 Nucleic acid positive COVID-19 pregnant women and 5 control individuals. The 162 proteins showed differential expression in COVID-19 pregnant women, of which 108 ... Read more
RESEARCH ARTICLE Updated Sep 08, 2021 PDF
J Clin Pharmacol Ther. 2021;2(2):JCPT-02-1017 | Open Access
Ankit Bhardwaj
Background: Polypharmacy, contribute to increase risk of adverse drug reaction morbidity, mortality, increase length of hospital stay, hospital revisits and readmissions. We aimed to evaluate the prevalence and trends of polypharmacy and Potentially Inappropriate Medications (PIMs) in elderly patients using updates Beers Criteria 2019. We try to assess the severity of adverse drug events using modified Hartwig and Siegel scale in ... Read more
RESEARCH ARTICLE Updated Aug 06, 2021 PDF
J Clin Pharmacol Ther. 2021;2(2):JCPT-02-1016 | Open Access
Ankit Bhardwajand Sangeeta Sharma
Background: Unlike first line Antiepileptic Drugs (AEDs) specific therapeutic range for Levetiracetam (LEV) has not been defined. The present study was conducted to find the mean serum LEV levels using population pharmacokinetics and to find out the correlation with the demographic and physiological determinants (age, gender, weight and dose) and concomitant antiepileptics drugs in the north Indian population.
Methods: ... Read more
RESEARCH ARTICLE Updated Aug 06, 2021 PDF
J Clin Pharmacol Ther. 2021;2(2):JCPT-02-1015 | Open Access
Palanisamy Sivanandy and Tan Si Jie
Background: Antibiotic resistance is an alarming situation in the healthcare sector, where the practice of healthcare professionals plays a vital role in preventing antibiotics-related harm. A cross-sectional study was conducted to analyze the knowledge, attitude, perception, and practice of antibiotic use and resistance among the final year pharmacy students of a Malaysian private medical university.
Methods: A cross-sectional study was ... Read more
RESEARCH ARTICLE Updated Jul 30, 2021 PDF
J Clin Pharmacol Ther. 2021;2(1):JCPT-02-1014 | Open Access
Sharanya Shre ES, Ravi S and Ezhil Arasan R
Pharmacogenomics is a field with a futuristic goal of providing personalized medicine based on an individual’s genetic makeup. The field experiences an exponential growth of evidence and research that could enable physicians to to prescribe medicines to treat underlying conditions while enhancing the predictability of adverse reactions and efficacy of a drug for an individual. With the continued ... Read more
RESEARCH ARTICLE Updated Jul 13, 2021 PDF
J Clin Pharmacol Ther. 2021;2(1):JCPT-02-1013 | Open Access
Muniza Bai, Pratap Upadhya, Lakshmi Sandhya, Manju Rajaram and Biswajit Dubashi
Though Dasatinib is a second-generation tyrosine kinase inhibitor used for the first line therapy of CML, it is associated with the risk of pulmonary hypertension and pleural effusion. Pleural effusion due to Dasatinib is often reversible unlike pulmonary hypertension. Asymptomatic pleural effusion warrants only conservative management and regular follow up. For symptomatic effusions, dose reduction or dose interruption is recommended. ... Read more
CASE REPORT Updated Jul 07, 2021 PDF
J Clin Pharmacol Ther. 2021;2(1):JCPT-02-1012 | Open Access
Di Mascio T, Correard F, Montaleytang M, Honore S, Couderc AL, Villani P, Auquier P, Daumas A and Berbis J
Purpose: Given limited human resources in France’s healthcare system, this study aimed to identify the predictive factors of unintentional medication discrepancies (UD) (described as unintentionally changes, adds or omits medication taken by a user prior to admission) in the elderly, in order to help prioritize which patients should undergo Medication Reconciliation (MR) upon hospital admission.
Methods: A ... Read more
RESEARCH ARTICLE Updated Jul 05, 2021 PDF
J Clin Pharmacol Ther. 2021;2(1):JCPT-02-1011 | Open Access
Indu T, Sanjay S and Priyanka D
Autoimmune thyroid disease triggers because of T cells attack in immune system (in thyroid gland). AITD mainly comprises of two types, ‘Hashimoto’s thyroiditis’ (hypothyroidism) and ‘Grave’s Disease’ (thyrotoxicosis). India have ‘42 million’ people groups experiencing thyroid disease, likewise it has perceived that in contrast with men 80% women’s affect more ... Read more
REVIEW ARTICLE Updated Jun 28, 2021 PDF
J Clin Pharmacol Ther. 2021;2(1):JCPT-02-1010 | Open Access
P.G.J. Ter Horstand L.W. Mulder
To report a case of imatinib use in a vasectomized patient and the use of condoms. In September 2020, a 45 year-old- pre menopausal female contacted the Medication Pregnancy and Lactation policlinic of the Isala Clinics (MAZ, Zwolle, and The Netherlands) for advice about the medication used by her spouse. He was treated with imatinib 400 mg once daily and they were told ... Read more
CASE BLOG Updated Mar 25, 2021 PDF
J Clin Pharmacol Ther. 2021;2(1):JCPT-02-1009 | Open Access
Cunha UGV, Rocha FL, Carvalho FBCL and Duarte DB
Severe Major Depression (MD) in very elderly patients usually requires a rapid response due to an increase risk of suicide and a faster clinical deterioration. In this scenario, electroconvulsive therapy constitutes the treatment option available at present. Nevertheless, not every older depressive patient is fit for a procedure which involves anesthesia and possible cardiovascular side effects. In this context, ketamine ... Read more
CASE REPORT Updated Feb 25, 2021 PDF
J Clin Pharmacol Ther. 2021;2(1):JCPT-02-1008 | Open Access
Xia M, Meng G and Dong J
What is known and objectives: Lung cancer has become one of the leading causes of cancer-related morbidity and mortality. Oncolytic virotherapy is an emerging therapeutic modality that utilizes replication-competent viruses to destroy cancers. The aim of this study was to investigate the synergistic effect of NF-κB signaling pathway inhibitor and oncolytic measles virus vaccine against lung cancer and ... Read more
RESEARCH ARTICLE Updated Feb 11, 2021 PDF
J Clin Pharmacol Ther. 2021;2(1):JCPT-02-1007 | Open Access
Pacifici GM
Lopinavir is structurally similar to ritonavir but is 3- to 10-fold more potent against HIV-1. This agent is active against HIV-1 and HIV-2. Lopinavir is coformulated with ritonavir which is a CYP3A4 inhibitor. Ritonavir is a peptidomimetic HIV protease inhibitor and is active against HIV-1 and HIV-2. The formulation of lovirapin/ritonavir is available in tablets and in oral ... Read more
RESEARCH ARTICLE Updated Jan 11, 2021 PDF
J Clin Pharmacol Ther. 2020;1(1):JCPT-01-1006 | Open Access
Pacifici GM
Caspofungin (Cancidas®) is an echinocandin and inhibits 1,3-β-D-glucan synthesis which is an essential component of the fungal cell wall and is required for cellular integrity. Caspofungin exhibits fungicidal and fungistatic activities against Candida and Aspergillus species, respectively. Caspofungin is largely eliminated by N-acetylation, catalyzed by CYP3A4, and inhibition of this enzyme causes marked increase of Caspofungin ... Read more
RESEARCH ARTICLE Updated Dec 31, 2020 PDF
J Clin Pharmacol Ther. 2020;1(1):JCPT-01-1005 | Open Access
Asha K Rajan, Vedha pal Jeyamani S, Deepak Paul Denagaran, Franklin Jose, Nallabothula Manoj Kumar and Narendra Babu
Cabozantinib (CAB), a Tyrosine Kinase Inhibitor (TKI) is the first-line therapy for Metastatic Renal Cell Carcinoma (mRCC) updated recently. Reports on adverse reactions of CAB include cutaneous reactions in a RCC patient. Other TKI (Sunitinib) reported cases on drug induced acute interstitial nephritis. To illustrate this, we depict a case on CAB induced adverse reactions in a RCC patient after 1 ... Read more
CASE REPORT Updated Nov 20, 2020 PDF
J Clin Pharmacol Ther. 2020;1(1):JCPT-01-1004 | Open Access
Asmaa Mosselhy, MahaYousif Zein , Manal Abdelsalam and Shaimaa Abdelmalik Pessar
GDF-15 is a stress-induced cytokine of the TGF-β (transforming growth factor-β) super family, which increases during tissue injury and inflammatory states. Little is known about the relationship between Growth Differentiation Factor-15 (GDF-15), and anemia among children on regular hemodialysis.
Aim: The study aimed to evaluate the serum level of growth differentiation and factor-15 (GDF-15) and C-Reactive Protein (CRP) ... Read more
RESEARCH ARTICLE Updated Nov 12, 2020 PDF
J Clin Pharmacol Ther. 2020;1(1):JCPT-01-1003 | Open Access
Daniela Mariano Carvalho-Louro
In the practical clinical of Hepatology, the focus of daily life has been the treatment of patients with severe liver diseases, such as cirrhosis and liver cancer. Of all the liver diseases responsible for cirrhosis development, hepatitis C had made the most treatment progress. In a few years, it evolved from drugs with low efficacy and many side effects to ... Read more
LETTER TO EDITOR Updated Oct 28, 2020 PDF
J Clin Pharmacol Ther. 2020;1(1):JCPT-01-1002 | Open Access
Samir Kumar Patra
“Higher the mutation rate higher is the possibility to evolve” and “higher the possibility to evolve higher is the possibility of extinction”. I hypothesize that pharmacological acceleration of the rate of mutations in the viral progeny genomes would help to destroy the virus infectivity and/or virulence. It is clear from the history of viral diseases ... Read more
REVIEW ARTICLE Updated Oct 03, 2020 PDF
J Clin Pharmacol Ther. 2020;1(1):JCPT-01-1001 | Open Access
Nader Namazi
Due to the instability of most biomolecules during the adsorption process on a hydrophobic polymer, the polymer surface can be modified to suit proteins binding mechanism. Binding of a protein to a biomolecule involves specific interaction domains that require substrate specificity. Isolating such interaction domains and incorporating them into large polypeptide chains can provide protein-binding epitopes on the surface. These ... Read more
RESEARCH ARTICLE Updated Sep 07, 2020 PDF