J Clin Pharmacol Ther. 2024;5(2):JCPT-05-1058 | Open Access
Liu R, Shen L, Jiang H, Wang Z, Li D, Yan K and Fan Z
Introduction: Platelet activation may be involved in the pathophysiology of psoriasis contributing to increased cardiovascular risks. The study aimed to evaluate the association between platelet activation and psoriasis severity by investigating the values of novel activation markers.
Materials and methods: The levels of Immature Platelet Fraction (IPF), Immature Platelet Count (IPC), Mean Platelet Volume (MPV), and Platelet Distribution Width (... Read more
RESEARCH ARTICLE Updated Jun 05, 2024 PDF
J Clin Pharmacol Ther. 2024;5(2):JCPT-05-1057 | Open Access
Kaushal Lalita, Chand Duni, Kumari Alka, Arti, Arya Ekta and Chauhan Narendra Singh
Traditionally used "Restorative Herb", Thalictrum Foliolosum contains rich bioactive compounds with potent free radical scavenging properties. This study explored its potential to combat liver damage. Root extracts (methanolic, ethanolic, hydro alcoholic, aqueous) were assessed for their content of flavonoids and phenolics, known for their antioxidant effects. The study induced liver damage in rats using paracetamol and then evaluated ... Read more
RESEARCH ARTICLE Updated Jun 03, 2024 PDF
J Clin Pharmacol Ther. 2024;5(2):JCPT-05-1056 | Open Access
Sancilio Frederick, Dariani Magshoud, Singh Gurpreet, Sutariya Rakesh and Chavda Purvi
Psilocybin and its active metabolite, psilocin, are potent psychoactive tryptamines naturally prevalent in Psilocybin mushrooms. They are being investigated for possible therapeutic applications in the treatment of several neurological disorders, depression, post traumatic stress disorder, obsessive-compulsive disorder, anxiety, addiction, and cluster headaches. Recent reports have broadened these investigations to include treatments as anti-inflammatory agents that cross the blood-brain barrier. Although ... Read more
REVIEW ARTICLE Updated May 20, 2024 PDF
J Clin Pharmacol Ther. 2024;5(1):JCPT-05-1054 | Open Access
Reshma Kumari and Sanjay Kumar
Green tea, derived from the Camellia sinensis plant known for its retention of natural substances found in fresh leaves, ranks as the world's second most consumed beverage after water, with various pharmacologically active components including tea polyphenols, alkaloids, amino acids, polysaccharides, and volatile compounds, isolated and identified from it. Recent studies have highlighted green tea's versatile pharmacological activities ... Read more
RESEARCH ARTICLE Updated May 18, 2024 PDF
J Clin Pharmacol Ther. 2024;5(1):JCPT-05-1053 | Open Access
Yingying Yang, Zhigang Xiao, Jing Ouyang and Yan Guo
Myopia is a growing concern in adolescents worldwide. This retrospective case study evaluated the efficacy of combining 0.01% atropine with orthokeratology lenses to control myopia progression in children. Results from 33 patients showed a significant reduction in axial length growth with the combined treatment, without notable changes in UCVA and IOP. Significant improvements were seen in TBUT and pupil diameter. Age was ... Read more
RESEARCH ARTICLE Updated May 10, 2024 PDF