Clin Neurol Int. 2020;2(1):CNI-02-1014 | Open Access
Shibchurn Mithilesh
Study concept and design, acquisition of data, analysis and interpretation of data, drafting of the manuscript and critical revision of the manuscript for important intellectual content.
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CASE REPORT Updated Sep 23, 2020 PDF
Clin Neurol Int. 2020;1(2):CNI-01-1013 | Open Access
Prasad R, Rai A, Singh A, Mishra OP and Singh UK
Tuberculosis of Central Nervous System (CNS) has wide range of presentation among which tuberculoma is quite common, but giant tuberculoma mimicking brain tumour is very rare. We are reporting a seven year female, who had presented with altered sensorium and upper motor neuron type of weakness of all four limbs. Neuroimaging revealed intracranial space occupying lesion with mass effect suggestive ... Read more
CASE REPORT Updated Jun 10, 2020 PDF
Clin Neurol Int. 2020;1(2):CNI-01-1012 | Open Access
Sami Ayed AlShammary, Balaji Durisami, Lobna Saleem and Abdullah Al Tamimi
Objective: World Health Organization (WHO) has recognized access to palliative care as a basic human right. Even though, palliative care service had been established in Saudi Arabia over two decades, it is still limited to secondary and tertiary health institutions. Despite the fact that the primary care level is the first line in Saudi health system and covering ... Read more
RESEARCH ARTICLE Updated May 02, 2020 PDF
Clin Neurol Int. 2020;1(2):CNI-01-1011 | Open Access
Ezziane K, Bouallag M, Habchi N, Mahiou M and Bouzid K
A retrospective study was undertaken on 194 patients in pediatric age group with diagnosis of medulloblastoma, treated from 1994-2009 at our oncologic centre. For all the patients, the diagnosis was made after surgery. All patients received adjuvant chemotherapy. The combined modality of chemotherapy and radiotherapy results is satisfactory for loco regional control and survival and acceptable for toxicity in patients with ... Read more
SHORT COMMUNICATION Updated Apr 16, 2020 PDF
Clin Neurol Int. 2020;1(2):CNI-01-1010 | Open Access
Claudia Ferraris, Roberto Nerino, Antonio Chimienti, Giuseppe Pettiti, Corrado Azzaro, Giovanni Albani, Alessandro Mauro and Lorenzo Priano
A system for the automatic assessment of motor impairments in Parkinson’s Disease (PD) is presented. The interface, built around optical RGB-Depth devices, allows for tracking of hands and body movements during the performance of standard upper and lower limb tasks, as specified by the Unified Parkinson’s Disease Rating Scale (UPDRS). The assessment of the different tasks ... Read more
RESEARCH ARTICLE Updated Feb 14, 2020 PDF
Clin Neurol Int. 2020;1(2):CNI-01-1009 | Open Access
Shaktipal Patil, Amrapali Mhaiskar and Dharmendra Mundhada
Anxiety and depression like behavior induced by ethanol in mice is a consequence of changes in the CNS that are secondary to impaired serotonin and norepinephrine neurotransmitters. Treatments with selective norepinephrine or serotonin reuptake inhobitors are reported to produce beneficial effects in this model. Desvenlafaxine is reported to exhibit selective norepinephrine inhibitor. However, no report is available on ... Read more
RESEARCH ARTICLE Updated Jan 23, 2020 PDF
Clin Neurol Int. 2019;1(1):CNI-01-1008 | Open Access
Fragoso M, Salazar G, Hermida-Lama E, Saurina A, Larque Ana B, Quintana LF, García-Herrera A and Blasco M
We present a patient with MacDonald criteria of relapsing remitting multiple sclerosis treated with Alemtuzumab, who showed a rapidly progressive glomerulonephritis with complete loss of renal function. Anti-Glomerular Basement Membrane antibodies (GBM) and anti M-type phospholipase A2 receptor (PLA2R) antibodies were detected. Nine days before acute kidney injury, serum creatinine was normal and urine analysis only detected ... Read more
CASE REPORT Updated Dec 13, 2019 PDF
Clin Neurol Int. 2019;1(1):CNI-01-1007 | Open Access
Lawrence M Agius
Inclusion dynamics of various different components in plaque architecture allow for a seemingly active and passive series of reactivity’s as well borne out the significant deployment of lesions both within the myelin sheath and also of axons and as further compounded by patterned lesions that summate as axonal loss and as inflammatory demyelination. It is further ... Read more
MINI REVIEW Updated Dec 13, 2019 PDF
Clin Neurol Int. 2019;1(1):CNI-01-1006 | Open Access
Lawrence M Agius
Conglomerate dimensionality in the pathogenesis and initiation of injury to the myelin sheath and to the axon in multiple sclerosis indicates a concerted array of events within the markedly heterogeneous nature of a disease process that progresses essentially as a function of such directly acting heterogeneity. The simple phases of progression are derivative defines of injury that promote ... Read more
MINI REVIEW Updated Nov 27, 2019 PDF
Clin Neurol Int. 2019;1(1):CNI-01-1005 | Open Access
Roy G Beran
Status Epilepticus (SE) is a medical emergency for which there are numerous guidelines but little aimed to tailor treatment to the individual patient. Either benzodiazepines, especially midazolam, or, if ineffective, barbiturate anesthesia, is used to abort the SE thereby providing a window of opportunity to establish long acting Antiepileptic Medications (AEMs) offered in boluses, determined by AEM blood ... Read more
SHORT COMMUNICATION Updated Oct 15, 2019 PDF
Clin Neurol Int. 2019;1(1):CNI-01-1004 | Open Access
Michelle Kraslow, Melissa J Armstrong, Adolfo Ramirez-Zamora, Leonardo Almeida, Amir Besharat, Aparna Wagle Shukla, Irene A Malaty, Michael S Okun, Chris J Hass and Daniel Martinez-Ramirez
The role of exercise in Parkinson’s Disease (PD) has been studied extensively in the last decade. Recent evidence shows physical activity partially improves the motor and non-motor symptoms of the disease. In this new era of personalized medicine, it is crucial to better characterize the benefits of exercise in PD. In the present review, we discuss the most ... Read more
REVIEW ARTICLE Updated Jul 15, 2019 PDF
Clin Neurol Int. 2019;1(1):CNI-01-1003 | Open Access
Divya R and Ashok V
During late 1970’s, Japan witnessed a new and grave hazard called “Karoshi” among the working population. Karoshi is term
used in social medicine, which means death due to overwork. Death of a 29-years-old male worker in the shipping department in 1969 was the first reported case of Karoshi.
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EDITORIAL Updated Jul 13, 2019 PDF
Clin Neurol Int. 2019;1(1):CNI-01-1002 | Open Access
Objectives: This research was conducted to find out the prevalence of depressive symptoms and assess the symptomatology in adolescent students of Nepal.
Background: Depressive symptoms are prevalent among school going adolescents and there is a significant relationship between prevalence of depression and socio-demographic characteristics of adolescent students. The objective was to study the socio-demographic correlates ... Read more
RESEARCH ARTICLE Updated May 08, 2019 PDF
Clin Neurol Int. 2018;1(1):CNI-01-1001 | Open Access
Luca Marsiliand Gallerini S
Vertebral Artery Dissection (VAD) is an important cause of stroke in the young adult frequently underdiagnosed, as symptoms are various and subtle in their early manifestation. VAD might be asymptomatic at onset in almost 50% of cases, but when symptoms are present, they mainly consist in local posterior neck pain and occipital cephalalgia, associated or not to other neurological symptoms ranging ... Read more
COMMENTARY Updated Oct 29, 2018 PDF